发明名称 |
Rotational intrathecal analgesia |
摘要 |
A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a μ-, δ-, or &kgr;-opioid receptor agonist for a first period of time, followed by intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor-like receptor 1 (ORL-1) agonist for a second period of time. The intrathecal drug administration of the first and second periods of time may be repeated a plurality of times without attaining tolerance in the mammal to either drug. Implantable apparatus for rotational administration of the active agents is also disclosed.
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申请公布号 |
US7737118(B2) |
申请公布日期 |
2010.06.15 |
申请号 |
US20020187454 |
申请日期 |
2002.07.01 |
申请人 |
OMEROS CORPORATION;REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DEMOPULOS GREGORY A.;PALMER PAMELA PIERCE |
分类号 |
A61K38/10;A61K45/06;A61K31/4436;A61K31/4439;A61K31/445;A61K31/4468;A61K31/4535;A61K31/485;A61K38/00;A61K38/07;A61K38/08;A61M5/142;A61M5/168;A61M37/00;A61P25/04;A61P25/36;A61P43/00 |
主分类号 |
A61K38/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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