发明名称 |
TORSIN, TORSIN GENES, AND METHODS OF USE |
摘要 |
The present invention relates, in general, to torsin genes, preferably, torsin A which encodes the torsion dystonia gene, DYT1. In particular, the present invention relates to nucleic acid molecules coding for the torsin protein; purified torsin proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to torsin proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding torsin proteins; a method of detecting nucleic acids encoding torsin proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with torsion dystonia; therapeutic uses; and methods of preventing torsion dystonia in an animal.
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申请公布号 |
CA2294472(C) |
申请公布日期 |
2010.06.15 |
申请号 |
CA19982294472 |
申请日期 |
1998.06.19 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
OZELIUS, LAURIE J.;BREAKEFIELD, XANDRA |
分类号 |
A01K67/027;C12N15/11;A61K38/00;A61P25/14;A61P43/00;C07K14/00;C07K14/435;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/12;C12N15/09;C12P21/08;C12Q1/68;C12R1/91;G01N33/53;G01N33/566 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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