发明名称 |
METHOD OF PREPARING ADENOSINE-RESISTANT ANTI-TUMOR T LYMPHOCYTES FOR ADOPTIVE IMMUNOTHERAPY |
摘要 |
<p>In the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing immune cells that are highly active in vivo. The immune cells may be expanded in vitro in the presence of an adenosine receptor agonist or an antisense nucleic acid that downregulates expression of an adenosine receptor, for example. The immune cells may be tumor-infiltrating lymphocytes (TIL), cytotoxic T lymphocytes (CTL), natural killer (NK) cells, or lymphokine-activated killer (LAK) cells, for example. The methods described herein may be used to treat a number of diseases including cancer, infectious diseases, and immunodeficiencies.</p> |
申请公布号 |
WO2010065959(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
WO2009US67011 |
申请日期 |
2009.12.07 |
申请人 |
NORTHEASTERN UNIVERSITY;SITKOVSKY, MICHAIL, V.;OHTA, AKIO |
发明人 |
SITKOVSKY, MICHAIL, V.;OHTA, AKIO |
分类号 |
C12N5/0783;A61K35/14;A61K35/26;A61P31/00;A61P35/00;A61P37/00;C12N5/02;C12N5/0781 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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