发明名称 |
ANNEXINA2 AS IMMUNOLOGICAL TARGET |
摘要 |
AnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. AnnexinA2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane AnnexinA2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. The cytoplasmic to cell surface translocation of AnnexinA2 expression is critical for pancreatic cancer cell invasion. In addition, phosphorylation of AnnexinA2 at Tyrosine 23 is important for its localization to the cell surface and for the invasion of pancreatic cancer cells. Finally, loss of AnnexinA2 leads to the loss of the Epithelial-Mesenchymal Transition. |
申请公布号 |
WO2010065613(A2) |
申请公布日期 |
2010.06.10 |
申请号 |
WO2009US66374 |
申请日期 |
2009.12.02 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;JAFFEE, ELIZABETH MARION;HUANG, LANQING;ZHENG, LEI |
发明人 |
JAFFEE, ELIZABETH MARION;HUANG, LANQING;ZHENG, LEI |
分类号 |
A61K39/395;A61K38/16;A61K38/17;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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