TRANSGENIC ANIMAL MODEL FOR MODELLING PATHOLOGICAL ANXIETY, A METHOD FOR IDENTIFYING COMPOUNDS FOR TREATMENT OF DISEASES OR DISORDERS CAUSED BY PATHOLOGICAL ANXIETY AND A METHOD FOR USING WFS1 PROTEIN AS A TARGET FOR IDENTIFYING EFFECTIVE COMPOUNDS AGAINST PATHOLOGICAL ANXIETY

摘要

The invention discloses the transgenic animal model for pathological anxiety, the method to generate this model, the method to test drugs and drug candidates for the treatment of pathological anxiety and the method to use Wfs1 as target for screening of new anxiolytic drugs to treat pathological anxiety. This animal model is useful to test potential drug candidates for the treatment of diseases caused by pathological anxiety and to screen therapeutic compounds for the psychiatric disorders caused by reduces stress-tolerance and deficiency in adaptation to environmental challenges.