PHARMACEUTICAL COMPOSITIONS AND METHODS OF SINONASAL DELIVERING THE SAME

摘要

The present invention provides a pharmaceutical composition comprising a chemical compound or a herb extract or the combination having at least one of the activities of antiviral, antibacterial, antifungal, anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, for the treatment and prevention of a disease of a mammal. The present invention also provides a system for delivering the composition to the hard-to-reach sinuses of a mammal to reduce the load of the pathogen, to reduce the amount of inflammatory mediators, to heal pathological changes, and collectively to treat a disease of a mammal, such as allergic fungal rhinosinusitis. The invented method of treating a human disease reduces infectious and inflammatory agents without causing antibiotic resistance or adverse event. The present invention additionally provides a kit for collecting the nasal wash specimen to analyze how much drug is administered into sinonasal cavities or to determine the load of microbes in rhino-sinuses.