摘要 |
Compounds of formula (I), or formula (II) or a pharmaceutically acceptable salt of formula (I) or formula (II), wherein: R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl; R2 is methyl or haloalkyl; R4 is hydroxyl, carbonyloxy, or carbonyldioxy; and R3 is aliphatic, aryl, aralkyl, or alkylaryl; and R5, R6, R7 and R8 are each individually H, halogen, alkoxy, alkyl, haloalkyl, aryl, nitro, cyano, amino, amido, acyl, carboxyl, substituted carboxyl, or -SO2R10, wherein R10 is H, alkyl, amino or haloalkyl; provided that in formula (I), R5 and R7 are not both H or R6 is not H or methoxy; and in formula (II) that if R4 is carbonyldioxy then R7 is not methoxy.
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申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA D.B.A.THE DEPARTMENT OF V ETERANS AFFAIRS;OREGON HEALTH & SCIENCE UNIVERSITY;MEDICINES FOR MALARIA VENTURE;UNIVERSITY OF SOUTH FLORIDA |
发明人 |
RISCOE, MICHAEL K.;KELLY, JANE X.;WINTER, ROLF W.;HINRICHS, DAVID J.;SMILKSTEIN, MARTIN J.;NILSEN, AARON;MONASTYRSKYI, ANDRII;CROSS, RICHARD M.;BURROWS, JEREMY;KYLE, DENNIS;MANETSCH, ROMAN;FLANIGAN, DAVID L. |