发明名称 |
Genome editing in rats using zinc-finger nucleases |
摘要 |
Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. |
申请公布号 |
AU2009322964(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
AU20090322964 |
申请日期 |
2009.12.03 |
申请人 |
SANGAMO BIOSCIENCES, INC.;SIGMA ALDRICH COMPANY |
发明人 |
XIAOXIA CUI;ARON M. GEURTS;FYODOR URNOV |
分类号 |
A01K67/027;C12N15/11 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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