| 发明名称 |
COMPLEX OF BIOLOGICALLY ACTIVE RECOMBINANT PROTEIN WITH POLYSIALIC ACID |
| 摘要 |
FIELD: chemistry; biochemistry. ^ SUBSTANCE: invention relates to biotechnology, in particular to obtaining protein complexes and can be used in medicine. A complex of biologically active recombinant protein is obtained, which is non-covalently bonded to polysialic acid which is inactive in aqueous solution at pH 4.4-4.7 which has prolonged therapeutic effect and has general formula: ^ where m=20-110; n=1-4; P is biologically active recombinant protein. ^ EFFECT: invention enables to obtain a complex of biologically active recombinant protein with polysialic acid, having stability and prolonged effect. ^ 6 dwg, 2 tbl, 15 ex |
| 申请公布号 |
RU2391354(C1) |
申请公布日期 |
2010.06.10 |
| 申请号 |
RU20080140687 |
申请日期 |
2008.10.15 |
| 申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII NAUK INSTITUT BIOORGANICHESKOJ KHIMII IM. AKADEMIKOV M.M. SHEMJAKINA I JU.A. OVCHINNIKOVA RAN, ROSSIJSKAJA FEDERATSIJA, OT IMENI KOTOROJ VYSTUPAET FEDERAL'NOE AGENTSTVO PO NAUKE I INNOVATSIJAM |
发明人 |
BEZUGLOV VLADIMIR VILENOVICH;GRETSKAJA NATAL'JA MIKHAJLOVNA;BOBROV MIKHAIL JUR'EVICH;AKIMOV MIKHAIL GENNADIEVICH;BAIRAMASHVILI DMITRIJ IL'ICH;SHIBANOVA ELENA DMITRIEVNA;KLINOV DMITRIJ VLADIMIROVICH;MIROSHNIKOV ANATOLIJ IVANOVICH |
| 分类号 |
C07K19/00 |
主分类号 |
C07K19/00 |
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