发明名称 |
Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue and/or fever |
摘要 |
The present invention is directed to therapeutic methods using IL-6 antagonists such as an AbI antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. |
申请公布号 |
AU2009323008(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
AU20090323008 |
申请日期 |
2009.11.24 |
申请人 |
ALDER BIOPHARMACEUTICALS, INC. |
发明人 |
JEFFREY T. L. SMITH;RANDALL C. SCHATZMAN;MARK LITTON;JOHN LATHAM |
分类号 |
C07K16/24;A61K39/395;A61P37/06 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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