发明名称 |
Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
摘要 |
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided. |
申请公布号 |
AU2010202054(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
AU20100202054 |
申请日期 |
2010.05.20 |
申请人 |
ABGENIX, INC. |
发明人 |
RICHARD WEBER;XIAO FENG;ORIT FOORD;LARRY GREEN;JEAN GUDAS;BRUCE KEYT;YING LIU;PALANI RATHANASWAMI;ROBERT RAYA;XIAO DONG YANG;JOSE CORVALAN;IAN FOLTZ;XIAO-CHI JIA;JASPAL KANG;CHADWICK T. KING;SCOTT L. KLAKAMP;QIAOJUAN JANE SU |
分类号 |
A61K39/395;A61K39/44;A61K47/48;C07H21/04;C07K14/71;C07K16/22;C07K16/28;C07K16/42;C07K17/00;C12N;C12N5/06;C12N5/12;C12P21/08;G01N33/53;G01N33/552;G01N33/577 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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