发明名称 |
HUMANIZED ANTI-RAGE ANTIBODY |
摘要 |
Compositions comprising antigen binding polypeptides that bind specifically to Receptor For Advanced Glycation End-product (RAGE) and comprises: one or more complementarity determining regions (CDRs) with improved binding efficiency over a parental monoclonal antibody to RAGE are described. Antibodies containing the CDR's and methods of treating a RAGE-related disease or disorder comprising administering to the subject a therapeutically effective amount of the compositions of the invention are also provided.
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申请公布号 |
US2010143349(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
US20090540038 |
申请日期 |
2009.08.12 |
申请人 |
WYETH |
发明人 |
HUFTON SIMON EVAN;FINLAY WILLIAM JAMES JONATHAN;CUNNINGHAM ORLA MARGARET;SHEEHAN ALFREDO DARMANIN;GERMAINE XUEMEI;LAMBERT MATTHEW ALLISTER |
分类号 |
A61K39/395;A61P1/00;A61P3/10;A61P9/00;A61P15/00;A61P19/02;A61P25/00;A61P27/02;A61P29/00;A61P31/04;A61P35/00;C07H21/04;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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