1- (BIPHENYL-4-YLMETHYL) IMIDAZOLIDINE-2, 4-DIONE DERIVATIVES AND THEIR USE AS CB2 RECEPTOR AGONISTS

摘要

The invention relates to A 1 -(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivative having the general Formula (I) wherein R1 is H, (C1-6)alkyl (optionally substituted with oxo, OR4, COOR5, halogen or CN), (C2-6)alkenyl, (C2-6)alkynyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl; R2 and R2' are independently H or (C1-3)alkyl; or R2 and R2' form together with the carbon atom to which they are bound a (C3-5)cycloalkyl group;R3 represents H or 1 to 4 F substituents; Y represents Formula (II) or NR8R9; X represents CHR6, CF2, O, S, SO or SO2; R4 and R5 are (C1-6)alkyl; R6 is H, OR7 or CN; R7 is (C1-3)alkyl; R8 is (C5-7)cycloalkyl comprising a heteroatom selected from O, S, SO and SO2; R9 is H or (C1-4)alkyl; o and m represent the ortho or meta position of the substituent Y-CH2; or a pharmaceutically acceptable salt thereof; as well as to the use of said 1 -(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivatives as CB2 receptor agonists in the treatment of pain such as for example peri-operative pain, chronic pain, neuropathic pain, cancer pain and pain and spasticity associated with multiple sclerosis.