用于治疗高血压的取代的氘富集的噻吩

摘要

本文公开了式I的取代的嘧啶系内皮缩血管肽调节剂、其制备方法、其药物组合物及其使用方法。

主权项

1.具有结构式I的化合物、或其药学上可接受的盐、溶剂合物或前药：其中：R₁选自氯化物和Z选自R₂、R₃、R₄、R₅、R₆、R₇、R₈、R₉、R₁₀、R₁₁、R₁₂、R₁₃、R₁₄、R₁₅、R₁₆、R₁₇、R₁₈、R₁₉、R₂₀、R₂₁、R₂₂、R₂₃、R₂₄、R₂₅、R₂₆、R₂₇、R₂₈、R₂₉、R₃₀和R₃₁独立地选自氢和氘；且R₂、R₃、R₄、R₅、R₆、R₇、R₈、R₉、R₁₀、R₁₁、R₁₂、R₁₃、R₁₄、R₁₅、R₁₆、R₁₇、R₁₈、R₁₉、R₂₀、R₂₁、R₂₂、R₂₃、R₂₄、R₂₅、R₂₆、R₂₇、R₂₈、R₂₉、R₃₀和R₃₁中的至少一个是氘。