发明名称 |
Cells comprising codon optimized lentiviral particles |
摘要 |
A method of producing a replication defective retrovirus comprising transfecting a producer cell with the following:
iii) a retroviral genome;
iv) a nucleotide sequence coding for retroviral gag and pol proteins; and
iii) nucleotide sequences encoding other essential viral packaging components not encoded by the nucleotide sequence of (ii); characterised in that the nucleotide sequence coding for retroviral gag and pol proteins is codon optimised for expression in the producer cell. |
申请公布号 |
EP2194137(A2) |
申请公布日期 |
2010.06.09 |
申请号 |
EP20100158183 |
申请日期 |
2001.04.18 |
申请人 |
OXFORD BIOMEDICA (UK) LIMITED |
发明人 |
KINGSMAN, ALAN JOHN;KIM, NARRY;KOTSOPOULOU, EKATERINI;ROHLL, JONATHAN;MITROPHANOUS, KYRIACOS |
分类号 |
C12N7/01;C12N15/09;A61K35/76;A61K48/00;C07K14/155;C07K14/16;C12N5/10;C12N7/00;C12N7/02;C12N7/04;C12N15/49;C12N15/867 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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