Nucleic acids encoding immunoglobins carrying gp100 and TRP2 epitopes

摘要

The present invention provides a nucleic acid which comprises a non-specific promoter and a sequence that encodes a recombinant antibody. The antibody molecule has heterologous T cell epitopes therein such that the antibody cannot take its native conformation when the nucleic acid is expressed. The heterologous T cell epitopes are:
GTGRAMLGTHTMEVTVYH in CDRH1 and CDRL3
SVYDFFVWL in CDRH2, and
WNRQLYPEWTEAQRLD in CDRH3 and CDRL1 Administration of the nucleic acid results in an immune response against the T cell epitopes,