发明名称 |
Medicinal uses of mu-opioid receptor agonists |
摘要 |
The present invention provides methods for stimulating mu-opioid receptors with agonist peptides in a mammal in need thereof. The methods comprise administering to the mammal an effective amount of a selective mu-opioid receptor agonist peptide that comprises at least two α-amino acid residues. At least one of the amino acid residues has a positive charge. The amino acid residue in the first position is a tyrosine or tyrosine derivative. The amino acid in the second position is a D-α-amino acid. The present invention also provides methods of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the peptides.
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申请公布号 |
US7732398(B2) |
申请公布日期 |
2010.06.08 |
申请号 |
US20060427606 |
申请日期 |
2006.06.29 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC.;CLINICAL RESEARCH INSTITUTE OF MONTREAL |
发明人 |
SZETO HAZEL;SCHILLER PETER W. |
分类号 |
A61K38/00;A61K38/07;A61K38/08;A61K38/12 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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