| 摘要 |
<p>It is described a process for producing dibenzothiazepine derivatives of formula (5), such as dibenzo[b,f][1,4]thiazepin- 11-one, which are usable as the starting material for producing 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperazinyldibenzothiazepine derivatives which are useful as a psychotropic drug. This method comprises steps: reaction of nitrobenzene, reduction of the obtained 2-nitro-2'-carboxy-diphenylsulfide derivative and subjection of the obtained 2-amino-2'-carboxy-diphenylsulfide derivative to a dehydration-condensation reaction.</p> |
