发明名称 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS
摘要 The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein.
申请公布号 HK1118857(A1) 申请公布日期 2010.06.04
申请号 HK20080110130 申请日期 2008.09.11
申请人 FIVE PRIME THERAPEUTICS, INC. 发明人 WILLIAMS, LEWIS, T.;BOSCH, ELIZABETH;DOBERSTEIN, STEPHEN;HESTIR, KEVIN;HOLLENBAUGH, DIANE;LEE, ERNESTINE;QIN, MINMIN;SADRA, ALI;WONG, JUSTIN;WU, GE;ZHANG, HONGBING
分类号 C07K;C12N 主分类号 C07K
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