RECOMBINANT ADENOVIRUS EXPRESSING SMALL INTERFERENCE RNA TO INHIBIT FOOT-AND-MOUTH DISEASE VIRUS
摘要
PURPOSE: A recombinant adenovirus expressing siRNA for suppressing and preventing foot-and-mouth virus is provided to generate siRNA targeting foot-and-mouth virus 2B and 3C genes and to ensure antiviral effect. CONSTITUTION: A recombinant adenovirus comprises a nucleotide of sequence number 3 or 5 and complementary nucleotide thereof(sequence number 4 or 6). An siRNA which specifically binds to the foot-and-mouth virus is synthesized from a DNA having a nucleotide of sequence number 1 or 2, or complementary nucleotide thereof. An antiviral formulation for foot-and-mouth contains the recombinant adenovirus expressing siRNA as an active ingredient.
申请公布号
KR20100059035(A)
申请公布日期
2010.06.04
申请号
KR20080117663
申请日期
2008.11.25
申请人
REPUBLIC OF KOREA(MANAGEMENT : MINISTRY FOR FOOD,AGRICULTURE, FORESTRY AND FISHERIES. NATIONAL VETERINARY RESEARCH AND QUARANTINE SERVICE(NVRQS))
发明人
KIM, SU MI;PARK, JONG HYEON;LEE, KWANG NYEONG;KO, YOUNG JOON;PARK, JEE YONG;JOO, YI SEOK