发明名称 |
ANTI-CXCR1 COMPOSITIONS AND METHODS |
摘要 |
The present invention provides methods of treating cancer by administering an IL8-CXCR1 pathway inhibitor (e.g., an anti-CXCR1 antibody or Repertaxin) alone or in combination with an additional chemotherapeutic agent such that non-tumorigenic and tumorigenic cancer cells in a subject are killed. The present invention also provides compositions and methods for detecting the presence of and isolating solid tumor stem cells in a patient (e.g., based on the presence of CXCR1 or FBXO21).
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申请公布号 |
US2010136031(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
US20090616579 |
申请日期 |
2009.11.11 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
WICHA MAX S.;GINESTIER CHRISTOPHE |
分类号 |
A61K39/395;A61K31/18;A61P35/00;C12N5/095;C12Q1/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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