发明名称 |
A CATALYTIC ASYMMETRIC METHOD FOR THE PREPARATION OF THE PACLITAXEL (TAXOL) C-13 SIDE-CHAIN DERIVATIVES AND ITS USE IN THE PREPARATION OF TAXANE DERIVATIVES |
摘要 |
<p>A new catalytic asymmetric two-step or one-pot method for the preparation of the C-13 side-chain of paclitaxel (Taxol) and derivatives of the general formula (I) in the form of an acid, salt or ester, in which R represents an aryl group or alkyl group, R1 represents an aryl group or alkyl group, Y represents O, H or alkyl, and X1 represent -CH2-Ph, alkyl, aryl, SiR3 (where the silyl group is a common protective group) or other suitable protective group.</p> |
申请公布号 |
WO2010062239(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
WO2009SE51237 |
申请日期 |
2009.11.02 |
申请人 |
CORDOVA, ARMANDO;DZIEDZIC, PAWEL;KULLBERG, MARTIN |
发明人 |
CORDOVA, ARMANDO;DZIEDZIC, PAWEL;KULLBERG, MARTIN |
分类号 |
C07C233/83;C07C51/235;C07C251/28 |
主分类号 |
C07C233/83 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|