发明名称 |
METHODS OF MODULATING ANGIOGENESIS |
摘要 |
The present inventors discovered that PKC&egr; is necessary for VEGF signaling through PI3K/Akt-dependent pathways and is involved in MAPK-dependent pathways, thus regulating eNOS activity and DNA synthesis, respectively. Thus differential manipulation of PKC&egr; activity can be used to modify VEGF effects in conditions in which modulation of angiogenesis is desirable (e.g., for treatment of diabetic proliferative retinopathy or to enhance angiogenesis for treatment of peripheral and myocardial ischemia).
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申请公布号 |
US2010135995(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
US20090510201 |
申请日期 |
2009.07.27 |
申请人 |
JOSLIN DIABETES CENTER, INC. |
发明人 |
MADSEN CHRISTIAN RASK;KING GEORGE LIANG |
分类号 |
A61K39/395;A61K31/7088;A61K38/00;C12Q1/48;C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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