| 发明名称 |
OLIGORIBONUCLEOTIDE OR PEPTIDE NUCLEIC ACID CAPABLE OF INHIBITING ACTIVITY OF HEPATITIS C VIRUS |
| 摘要 |
<p>An analysis is pursued mainly on siE sequences, which have been believed to have an RNAi activity against HCV virus RNA, by selecting mainly D5-50 and D5-197 regions occurring in an IRES region, and siRNA sequences each having a more effective RNAi activity against hepatitis C virus RNA are successfully identified. It is also found that each of the siRNA sequences also has a significant inhibitory effect on in vivo HCV proliferation.</p> |
| 申请公布号 |
WO2010061881(A1) |
申请公布日期 |
2010.06.03 |
| 申请号 |
WO2009JP69934 |
申请日期 |
2009.11.26 |
| 申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA;TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH;KOHARA, MICHINORI;SUDO, MASAYUKI |
发明人 |
KOHARA, MICHINORI;SUDO, MASAYUKI |
| 分类号 |
C12N15/113;A61K31/7088;A61K31/713;A61K35/76;A61K48/00;A61P31/14;A61P31/16;A61P31/18 |
主分类号 |
C12N15/113 |
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