发明名称 |
NOVEL ANTIBIOTIC PEPTIDE DERIVED FROM RIBOSOMAL PROTEIN L 1 OF HELICOBACTER PYLORI AND USE THEREOF |
摘要 |
<p>The present invention relates to a new antibiotic peptide and a usage thereof, which are derived from ribosomal protein Ll, RPLl of Helicobacter pylori. Specifically, the antibiotic peptide comprising the amino acid sequence of SEQ. ID. NO:1 derived from ribosomal protein Ll, RPLl of Helicobacter pylori is substituted with a Phenylalanine, which is situated at the fist and the eighth position from the antibiotic peptide, or in addition an Asparagine, which is situated at the thirteenth position of the antibiotic peptide, is substituted with lysine, wherein the produced peptides have maintained more decreased cytotoxicity when comparing to the existing antibiotic peptides and can be used as a safe antibiotics by showing more antibacterial activity.</p> |
申请公布号 |
WO2010061984(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
WO2008KR06938 |
申请日期 |
2008.11.25 |
申请人 |
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY;HAHM, KYUNG-SOO;PARK, YOONKYUNG;PARK, SEONG-CHEOL;LEE, JONG-KOOK |
发明人 |
HAHM, KYUNG-SOO;PARK, YOONKYUNG;PARK, SEONG-CHEOL;LEE, JONG-KOOK |
分类号 |
C07K14/205;C07K14/195 |
主分类号 |
C07K14/205 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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