| 摘要 |
PROBLEM TO BE SOLVED: To provide an easy to swallow oral medicament composition. SOLUTION: The easy to swallow pharmaceutical composition consists of one or several coated particles with a core which contains an active substance and a coating with one or several layers. The coating layers (one or more layers) contain at least one hydratable, pharmaceutically acceptable polymer which is in contact with saliva or water forms a coherent, moldable, viscous mass with a slippery surface which does not adhere to the mucous membranes of the mouth and which prevents the active substance-containing particles from leaving the mass and releasing the active substance in the mouth cavity. The coating layer or the outermost coating layer contains an effective amount of at least one salivation promoting agent. The formation of a moldable, slippery mass and the taste-masking properties of the coating make the composition suitable in particular for administering highly dosed or bad tasting active substances, and can preferably be swallowed even without any liquid. COPYRIGHT: (C)2010,JPO&INPIT
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