发明名称 |
RECOMBINANT NORTH AMERICAN TYPE 1 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND METHODS OF USE |
摘要 |
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major problem in the pork industry worldwide. The inclusion of markers in vaccines will allow for diagnostic differentiation of vaccinated animals from those naturally infected with wild-type virus. Using a cDNA infectious clone of North American Type 1 PRRSV, a recombinant green fluorescent protein (GFP) tagged PRRSV has been made, containing deletion of an immunogenic epitope, ES4, in the nsp2 region. GFP and ES4 epitope-based ELISAs compliment the marker identification.
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申请公布号 |
US2010136047(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
US20080145231 |
申请日期 |
2008.06.24 |
申请人 |
SOUTH DAKOTA STATE UNIVERSITY |
发明人 |
FANG YING;NELSON ERIC A.;HENNINGS JANE |
分类号 |
A61K39/12;A61P31/14;C12N7/01;C12Q1/70 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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