HYALURONAN SYNTHASES AND METHODS OF MAKING AND USING SAME
摘要
A functionally active hyaluronan synthase having at least one modified amino acid residue therein as compared to a corresponding functionally active native hyaluronan synthase such that the functionally active hyaluronan synthase has an altered enzymatic activity as compared to the corresponding functionally active native hyaluronan synthase is disclosed. The altered enzymatic activity may result in increased or decreased activity when compared to the corresponding native hyaluronan synthase, or the altered enzymatic activity may result in production of hyaluronan having an average molecular mass that is greater than or less than an average molecular mass of hyaluronan produced by the corresponding native hyaluronan synthase. Methods of producing hyaluronic acid utilizing a recombinant host cell having an expression construct encoding the functionally active hyaluronan synthase with altered enzymatic activity are also disclosed.
申请公布号
WO2007016221(A3)
申请公布日期
2010.06.03
申请号
WO2006US29145
申请日期
2006.07.28
申请人
THE BOARD OF REGENTS OF UNIVERSITY OF OKLAHOMA;DEANGELIS, PAUL, L.;WEIGEL, PAUL, H.;PUMMILL, PHILLIP