发明名称 NOVEL METHOD FOR THE SYNTHESIS OF ANTICANCER (POLY)AMINOALKYLAMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN
摘要 The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, which can be used in therapeutics as anticancer agents. The invention includes a step comprising the condensation of a primary amine reactant, the amine functions of which are not protected, with 4β-chloroacetamido-4'-epipodophyllotoxin in an aprotic polar organic solvent.
申请公布号 KR20100058536(A) 申请公布日期 2010.06.03
申请号 KR20107005172 申请日期 2008.09.23
申请人 PIERRE FABRE MEDICAMENT 发明人 GUMINSKI YVES;GROUSSEAUD MARTIAL;IMBERT THIERRY
分类号 C07D493/04;A61K31/343;A61P35/00 主分类号 C07D493/04
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