发明名称 |
NOVEL VARIABLE LYMPHOCYTE RECEPTOR, METHOD FOR SCREENING FOR PHAGE CAPABLE OF BINDING TO TARGET ANTIGEN, AND METHOD FOR PRODUCING VARIABLE LYMPHOCYTE RECEPTOR FOR TARGET ANTIGEN |
摘要 |
<p>Disclosed is a novel variable lymphocyte receptor (VLR) which can recognize an antigen that cannot be recognized by known molecules VLRA and VLRB. Also disclosed is a method for screening for a phage capable of binding to a target antigen, which utilizes the VLR. The VLR comprises one LRRNT, one LRRCT, and at least one LRR arranged between the LRRNT and the LRRCT, wherein the LRRCT has a motif comprising either the amino acid sequence (a) and/or the amino acid sequence (b) shown below. (a) Val-Lys-X1-Val-Asn-(X8)-Cys (b) Val-Lys-X1-Val-X1-Thr-(X7)-Cys (In the formulae (a) and (b), X represents an amino acid residue; and Xn represents an amino acid sequence composed of n amino acid residues Xs which are the same as or different from each other, wherein n represents a natural number.)</p> |
申请公布号 |
WO2010061892(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
WO2009JP69958 |
申请日期 |
2009.11.26 |
申请人 |
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY;KASAHARA MASANORI;KASAMATSU JUN;SUTOH YOICHI;FUGO KAZUNORI |
发明人 |
KASAHARA MASANORI;KASAMATSU JUN;SUTOH YOICHI;FUGO KAZUNORI |
分类号 |
C07K16/00;C12N15/09;C12P21/02;C12Q1/02;C12Q1/68;C40B60/12 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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