发明名称 Long chain N-alkyl compounds and oxa-derivatives thereof
摘要 Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
申请公布号 US2010137365(A1) 申请公布日期 2010.06.03
申请号 US20100656370 申请日期 2010.01.28
申请人 THOMAS JEFFERSON UNIVERSITY;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UNITED THERAPEUTICS CORPORATION 发明人 ZITZMANN NICOLE;BUTTERS TERRY D.;PLATT FRANCES M.;JACOB GARY S.;PICKER DONALD H.;CARROUEE SANDRA;FLEET GEORGE W.J.;DWEK RAYMOND A.;DURANTEL DAVID;MEHTA ANAND;BLOCK TIMOTHY M.
分类号 A61K31/445;C07D211/46;A61K31/00;A61K31/13;A61K31/16;A61K31/166;A61K31/40;A61K31/402;A61K45/00;A61K51/00;A61P31/12;A61P31/14;C07C231/12;C07C237/30;C07C237/42;C07D207/12 主分类号 A61K31/445
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