发明名称 |
ANTISENSE ANTIBACTERIAL METHOD AND COMPOUND |
摘要 |
A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases and has a targeting nucleic acid sequence of no fewer than 10 bases in length that is complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication. The compound binds to a target mRNA with a Tm of between 50° to 60° C. The relatively short antisense compounds are substantially more active than conventional antisense compounds having a targeting base sequence of 15 or more bases.
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申请公布号 |
US2010137408(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
US20090613428 |
申请日期 |
2009.11.05 |
申请人 |
GELLER BRUCE L;DEERE JESSE D;IVERSEN PATRICK L;WELLER DWIGHT D |
发明人 |
GELLER BRUCE L.;DEERE JESSE D.;IVERSEN PATRICK L.;WELLER DWIGHT D. |
分类号 |
A61K31/7088;A61P31/04;C07H21/02;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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