发明名称 |
FACTOR VII OR VIIA GLA DOMAIN VARIANTS |
摘要 |
<p>Gla domain variants of human Factor VII or human Factor VIIa, comprising 1-15 amino acid modifications relative to human Factor VII or human Factor VIIa, wherein a hydrophobic amino acid residue has been introduced by substitution in position 34; or having an amino acid substitution in position 36; and use of the variants for the treatment of intracerebral haemorrhage (ICH) or trauma.</p> |
申请公布号 |
EP1644504(B8) |
申请公布日期 |
2010.06.02 |
申请号 |
EP20040738925 |
申请日期 |
2004.06.18 |
申请人 |
BAYER HEALTHCARE LLC |
发明人 |
HAANING, JESPER, MORTENSEN;ANDERSEN, KIM, VILBOUR;BORNAES, CLAUS |
分类号 |
C12N15/57;A61K38/00;A61K38/36;A61K38/37;A61K38/48;C07K14/745;C12N9/64 |
主分类号 |
C12N15/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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