| 摘要 |
<p>The present invention is concerned with isoxazole-pyridine derivatives of formula (I) wherein: X is O or NH; R1 is phenyl, pyridinyl, or pyrimidinyl, each optionally substituted with 1, 2 or 3 halo, R2 is H or CH3 or CF3; R3, R4, R5, and R6 are each independently H optionally substituted C1-7alkyl optionally substituted C1-7alkoxy CN, halo, NO2, S-C1-7alkyl, S(O)-C1-7alkyl optionally substituted benzyloxy -C(O)-Ra, -C(O)-NRb Rc, or a pharmaceutically acceptable salt thereof. The compounds are active on the GABA A alpha5 receptor binding site and useful for the treatment of cognitive disorders, such as Alzheimer's disease.</p> |
