发明名称 |
METODOS Y KITS PARA DIAGNOSTICAR Y/O PRONOSTICAR EL ESTADO DE TOLERANCIA EN EL TRASPLANTE DE HIGADO. |
摘要 |
The long-term survival of transplanted grafts critically depends on the life-long administration of immunosuppressive drugs to prevent graft rejection. These drugs are very effective at preventing graft rejection, but they are also associated with severe side effects. Inventors have selected a set of genes whose expression characterizes the tolerant state in liver transplantation in humans. Based on the expression level profile of this set of genes, inventors provide a non-invasive method to assess diagnosis and/or prognosis of the tolerant state in liver transplantation in humans, and kits to perform it. These kits are simpler and cheaper than others based on a great number of genes, such as commercial microarrays with thousands of probes.
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申请公布号 |
ES2324751(B1) |
申请公布日期 |
2010.05.31 |
申请号 |
ES20070000073 |
申请日期 |
2007.01.04 |
申请人 |
INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI ISUNYER (IDIBAPS);CENTRE DE REGULACIO GENOMICA |
发明人 |
SANCHEZ FUEYO ALBERTO;MARTINEZ LLORDELLA MARC;PUIG PEY ISABEL;RIMOLA CASTELLA ANTONI;LOZANO SALVATELLA JUAN JOSE;SUMOY VAN DYCK LAURO |
分类号 |
C12Q1/68;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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