MANUFACTURING METHOD OF DEXIBUPROFEN SALT AND ORAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

PURPOSE: A method for preparing dexibuprofen salt and a pharmaceutical composition for oral administration containing the same are provided to enhance release rate and to reduce side effect. CONSTITUTION: A method for preparing a dexibuprofen salt comprises: a step of dissolving dexibuprofen and inorganic base or organic base in two kinds of more polar solvent; a step of adding acetone to crystallize; and a step of drying crystal. The inorganic base or organic base is arginine, lysine, histidine, ornithine, NH4OH, NaOH, or KOH. A pharmaceutical composition contains the dexibuprofen salt and pharmaceutically acceptable carrier. A pharmaceutical composition for oral administration is used in the form of tablet, capsule, granule, pill, or liquid.