CHEMICAL INHIBITOR OF SNAIL-P53 BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE COMPRISING THE SAME

摘要

PURPOSE: A chemical inhibitor for the bond between snail-p53 is provided to effectively treat K-Ras mutagenic cancer disease by inducing the revelation of the p-53 in K-Ras mutant cell strain. CONSTITUTION: A chemical inhibitor has a structure marked as a chemical formula 1. In the chemical formula 1, m is an integer of 0-10, n and p is 0 or 1. In the chemical formula 1, Z is selected from a group comprising NH(CH2)qCH3, -OH, 4-phenylpiperidine group, isobutylamine, and isobutyloxy group and q is integer of 0-9. A pharmaceutical composition for treating cancer disease contains a compound for inhibiting the bond of snail-p53 as an active ingredient.