| 发明名称 |
cDNA Encoding a Gene Bog (B5T Over-Expressed Gene) and its Protein Product |
| 摘要 |
Nucleic acids that encode novel polypeptides, designated in the present application as“BOG”(B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-β1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
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| 申请公布号 |
US2010129791(A1) |
申请公布日期 |
2010.05.27 |
| 申请号 |
US20070956680 |
申请日期 |
2007.12.14 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATE, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH & HUMAN SERVICE |
发明人 |
THORGEIRSSON SNORRI S.;WOITACH JOSEPH T.;ZHANG MINGHUANG |
| 分类号 |
C12Q1/68;C07H21/02;C07H21/04;C07K14/47;C12N5/00;C12N5/02;C12N9/12;C12N15/63;C12N15/85;C12P21/06;G01N33/573 |
主分类号 |
C12Q1/68 |
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