发明名称 |
MEMBRANE RESIDENT PEPTIDE IN ANTI-CANCER PEPTIDES CAUSES TUMOR CELL NECROSIS RATHER THAN APOPTOSIS OF CANCER CELLS |
摘要 |
An aspect of the invention provides a method of selectively necrosing cells, comprising: providing a plurality cells, including at least one cancer cell and at least one non-cancerous cell; and administering to the cells a compound, including an HDM-2 targeting component and a cytotoxic component attached to the HDM-2 targeting component, wherein said compound comprises a membrane-active form. |
申请公布号 |
WO2010040051(A3) |
申请公布日期 |
2010.05.27 |
申请号 |
WO2009US59380 |
申请日期 |
2009.10.02 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;PINCUS, MATTHEW, R.;MICHL, JOSEF |
发明人 |
PINCUS, MATTHEW, R.;MICHL, JOSEF |
分类号 |
A61K38/17;A61K47/48;A61P35/00;G01N33/50 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|