发明名称 |
Hypo-and hyper-acetylated meningococcal capsular saccharides |
摘要 |
Capsular saccharides derived from serogroups W135 and Y of Neisseria meningitidis have altered levels of O-acetylation at the 7 and 9 positions of their sialic acid residues, and can be used to make immunogenic compositions. Relative to unmodified native saccharides, derivatives of the invention are preferentially selected during conjugation to carrier proteins, and conjugates of the derivatives show improved immunogenicity compared to native polysaccharides. |
申请公布号 |
AU2008202708(B2) |
申请公布日期 |
2010.05.27 |
申请号 |
AU20080202708 |
申请日期 |
2008.06.19 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS S.R.L. |
发明人 |
FRANCESCO BERTI;PAOLO COSTANTINO |
分类号 |
A61K31/715;A61K39/095;C08B37/00 |
主分类号 |
A61K31/715 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|