| 摘要 |
Drugs 11 and other functional groups are attached to surfaces of nano-sized diamonds (NDs) 20 to enhance the efficacy of drugs 11 such as analgesics, cholesterol-reducing drugs and other substances. Such coatings are formed by covalently linking NDs to the drug 11. NDs 20, due to its small size and spherical shape exhibits a large surface area which enhances contact with other substances and therefore the chemical reactions. The large surface area of NDs 20 covered with active drugs allows greater access to active sites of the drugs and allows a large amount of substance to come in contact with other chemical entities enhancing the reactions. NDs 20 are also a solution stabilizer allowing enhanced concentration and solubility of coated NDs 20, enhancing the ability of the active sites of drugs 11 to be dissolved and come in contact with corresponding sites 13,15 of other entities enhancing their efficacy.
|
