ARGININE INACTIVATION OF VIRUSES

摘要

The present invention pertains to methods of using arginine to inactivate or reduce the infectious titer of enveloped viruses potentially present in biological compositions produced by eukaryotic cells (such as a antibodies or other therapeutic proteins). In some embodiments, inactivation or reduction of viral titers by exposure to arginine is achieved in a neutral (pH ~7) or near neutral (~pH 6 to ~pH 8) environment.