THERMOSENSITIVE COMPOSITION PREVENTING TISSUE ADHESION AND PREPARATION METHOD THEREOF

摘要

The present invention relates to a thermosensitive composition preventing tissue adhesion and a method for preparing the same. More specifically, the present invention relates to a thermosensitive composition preventing tissue adhesion which further contains a drug selectively inhibiting inflammatory response and a method for preparing the composition. The composition is fabricated through a chemical reaction by adding a cross-linking agent to an aqueous solution. The aqueous solution contains: a block copolymer containing a polyethyleneoxide block having the ability to suppress tissue adhesion, and a polymer with 10,000 to 1,000,000 g/mol of molecular weight which can be mixed with the copolymer. Also, the composition is characterized in that the differences of viscosity, absorbance of visible region, and stability between the upper and lower liquid layers are within 10% when centrifuging the composition. In addition, the method for preparing the composition enhances cross-linking homogenization and viscosity stability through simultaneous spraying and stirring methods without a reaction retardant. According to the present invention, floating debris on a fiber which is caused by uneven cross-linking can be not only prevented, but cross-linking homogenization and viscosity stabilization can also be enhanced. Therefore, the composition can be uniformly applied to a wound on a human body and has high stability and excellent effect of preventing tissue adhesion.