METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR

摘要

In accordance with the present invention, novel compounds have been discovered that are useful for a variety of therapeutic applications, e.g., for modulating amyloid-beta levels. Accordingly, invention compounds find use in the treatment of a variety of diseases. Compositions and kits comprising invention compounds are also provided. In one aspect of the present invention, there are provided compounds which have activity in modulating levels of amyloid-beta (AjS). As a result, such compounds are applicable for treating diseases associated with aberrant levels of Aß and/or any condition in which modulation of Aß levels provides a therapeutic effect. Preferably, compounds herein are useful in the treatment of neurodegenerative disorders, such as AD.