| 摘要 |
Described herein are methods for treating aneurysms, vascular occlusions, and vascular lesions. The methods comprise the use of an implantable medical device which includes a bioactive agent substrate associated with its surface. Liposomes are used to encapsulate the bioactive agent and are delivered either systemically or locally to the bloodstream. A means for liberating the bioactive agents from the liposomes is used once an appropriate location is chosen and the liposomes have distributed themselves through the vasculature. Once liberated, the bioactive agent can be sequestered by the bioactive agent substrate associated with the implantable medical device, and slowly released to impart a therapeutic effect on the surrounding tissues.
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