PYRAZOLE[1,5-a]PYRIMIDINE DERIVATIVE

摘要

FIELD: chemistry. ^ SUBSTANCE: present invention relates to a new pyrazole[1.5-a]pyrimidine derivative of formula [1]: , where ring A is a substituted pyrazole ring condensed with a neighbouring pyrimidine ring having formula , and group E is one of the following groups (ii)-(v): , and the rest of the radicals are defined in the description. The invention also relates to pharmaceutical compositions containing such compounds. ^ EFFECT: disclosed compositions and compositions have antagonistic effect on CB1 cannabinoid receptor. ^ 19 cl, 82 tbl, 500 ex