ORAL SOLID PHARMACEUTICAL FORMULATION OF THE TUBULIN INHIBITOR INDIBULIN
摘要
The present invention relates to a pharmaceutical formulation for oral administration of the poorly soluble and therefore hardly bioavailable tubulin inhibitor Indibulin and a process for its manufacture. In particular, there is provided a pharmaceutical formulation of lndibulin for oral administration comprising a granulate containing micronized lndibulin having a particle size of less than 20 µm for at least 99 vol.-% of the particles, at least one hydrophilic surfactant, and one or more capsulation excipients.
申请公布号
WO2006133835(A8)
申请公布日期
2010.05.27
申请号
WO2006EP05423
申请日期
2006.06.07
申请人
ZIOPHARM ONCOLOGY, INC.;ROESSLER, BERTHOLD;RAAB, GERHARD;REISSMANN, THOMAS
发明人
ROESSLER, BERTHOLD;RAAB, GERHARD;REISSMANN, THOMAS