发明名称 |
EQUINE DISEASE MODEL FOR HERPESVIRUS NEUROLOGIC DISEASE AND USES THEREOF |
摘要 |
Disclosed is an in vivo equine disease model and a method of preparing the disease model for equine herpesvirus-1 neurological disease comprising a horse having a low pre-exposure level of herpesvirus-specific CTL precursors wherein the horse is experimentally infected with a neuropathogenic strain of equine herpesvirus or a mutant thereof. Also disclosed is a method of quantifying the risk factors and predicting the development of clinical neurologic signs of equine herpesvirus-l neurological disease in a horse. Also described in the invention is the determination of the risk of developing the clinical neurologic signs by a mathematical equation. A new live, attenuated vaccine formulation is disclosed that is effective against neurologic disease due to equine herpesvirus-1. |
申请公布号 |
WO2010014241(A3) |
申请公布日期 |
2010.05.27 |
申请号 |
WO2009US04409 |
申请日期 |
2009.07.29 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION;ROSS, GLENDA |
发明人 |
ALLEN, GEORGE, P. |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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