| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to derivative of hyaluronic acid, where nonsteroid anti-inflammatory medical agent is joined to hyaluronic acid by means of covalent link, which contains partial structure of disaccharide unit of hyaluronic acid, to which anti-inflammatory medical agent is joined, being represented by the following formula (1): Y-CO-NH-R1-(O-R2)n (l) where Y-CO- represents one residue of disaccharide unit of hyaluronic acid; R2 represents a residue of nonsteroid anti-inflammatory medical agent represented by group Z-CO- or atom of hydrogen, provided that all R2 are not atom of hydrogen; -NH-R1-(O-)n represents spacer residue in compound-spacer represented by the formula H2N-R1-(OH)n, having hydroxyl groups in amount of n;R1 represents linear or ramified hydrocarbon group, containing from 2 to 12 atoms of carbon, which may have a substitute;-CO-NH- represents amide link of carboxyl group of hyaluronic acid as a component of hyaluronic acid saccharide with amides of compound-spacer;-O-CO- represents ester link of hydroxyl group of compound-spacer with carboxyl group in residue of nonsteroid anti-inflammatory medical agent, and n equals integer number from 1 to 3, where derivative of hyaluronic acid has an extent of susbstitution with nonsteroid anti-inflammatory medical agent from 5 to 50% mole per repeated unit of hyaluronic acid and carbonyl group in residue of hyaluronic acid, which represents component derivative of hyaluronic acid is available as participant in formation of amide link in process of binding with spacer-binding residue of nonsteroid anti-inflammatory medical agent or as free carboxyl group that does not participate in this process, according to extent of substitution of residue of nonsteroid anti-inflammatory medical agent. Invention also relates to solution and pharmaceutical agent for suppression of pain and/or suppression of inflammation and/or treatment of arthritis, derivative of hyaluronic acid, set and medical set for injection, including solution of hyaluronic acid derivative. ^ EFFECT: production of solution and pharmaceutical agent for suppression of pain and/or suppression of inflammation and/or treatment of arthritis. ^ 26 cl, 12 dwg, 1 tbl, 49 ex |
