SUBSTITUTED AMIDES, METHODS OF MAKING, USE THEREOF FOR THE TREATMENT OF DISEASES SUCH AS CANCER
摘要
Compounds of Formula I that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/ or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.
申请公布号
EP2188267(A2)
申请公布日期
2010.05.26
申请号
EP20080832237
申请日期
2008.09.19
申请人
CGI PHARMACEUTICALS, INC.
发明人
BLOMGREN, PETER A.;CURRIE, KEVIN S.;LEE, SEUNG H.;MITCHELL, SCOTT A.;XU, JIANJUN;SCHMITT, AARON C.;ZHAO, ZHONGDONG;ZHICHKIN, PAVEL E.;STAFFORD, DOUGLAS G.;KROPF, JEFFREY E.